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Sovan Lal Pal*, U. Jana, G. P. Mohanta and P. K. Manna


The objective of the present study was to formulate carvediloleudragit ® RS100 nanoparticles and investigate the physic-chemical characteristics of the prepared nanoparticles. The nanoparticles of carvedilol with eudragit® RS100 were formulated using the emulsion solvent evaporation. Several process parameters, i.e., drug/polymer ratio, aqueous phase volume and speed of sonication were considered to achieve optimal preparation condition. The physicochemical characteristics of nanoparticles were studies applying particle size analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, scanning electron microscopy and atomic force microscopy. The release rate of carvedilol from various drug/polymer nanoparticles was investigated as well. All the prepared formulation using eudragit® RS100 resulted in nano-range size particles (280-467 nm) as detected by Zeta Sizer. The entrapment efficiencies were observed for all the nanoparticles in a range of 67% to 91%. The nanoparticles of carvedilol- eudragit® RS100 displayed no chemical interaction between drug and polymer molecules. The SEM image revealed that particles were smooth, spherical in shape. The particle aggregation of the particles was observed by AFM study. The nanoparticles exhibited the slower release of drug in comparison with the intact drug and polymer molecules. According to the finding, formulation of carvedilol- eudragit® RS100 nanoparticles was able to improve physicochemical characteristics of the drug and possibly will enhance the antihypertensive effects of the drug following its oral administration.

Keywords: Carvedilol; nanoparticles; physic-chemical characteristics, eudragit® RS100, solvent evaporation.

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