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Abstract

ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF NEEM AND CLOVE EXTRACT AGAINST S.MUTANS AND C.ALBICANS-AN INVITRO STUDY

Dr. Sandesh Nagarajappa, Dr. Pratiksha Bathija*, Dr. Prashant Mishra, Dr. Vaibhav Bansal, Dr. Sonali Gupta and Dr. Shantanu Sontakke

ABSTRACT

Introduction: Dental caries is one of the public health concerns as oral health is integral to general well-being and relates to the quality of life. It is a chronic disease which often requires an invasive treatment along with antibiotic regimen. Since the microbial resistance to traditionally used antibiotics is increasing day by day, there is urgent need for development of new drug molecules which are effective affordable and non toxic. Objective: Present study was aimed to detect antibacterial and antifungal activity of Neem and Cloves against Streptococcus. Mutans and Candida.Albicans. Material And Method: Strains of S.mutans and C.Albicans and selective media for growing micro-organisms were procured. Antimicrobial activity was assessed using two methods, by determining Minimum Inhibitory Concentration (MIC) using Broth Dilution Method and determining Zone of Inhibition using well diffusion method on Mitis Salivarius Bacitracin (MSB) selective for S.mutans and Saboraud’s dextrose agar plates for C.albicans. One way ANOVA with post hoc analysis was done to compare the Antimicrobial activity of extracts and 0.2%Chlorhexidine. Results: MIC of neem was found to be 4.2mg/ml and 5mg/ml against S.mutans and C.albicans and 5.5mg/ml for cloves. Neem had highest antibacterial activity with a mean zone of inhibition of 11.4 mm followed by Chlorhexidine and Cloves whereas antifungal activity was highest for Chlorhexidine (14.4 mm )followed by Neem and Clove. Conclusion: The results of present work established that both plant extracts possess antimicrobial activity against common microbes present in oral cavity responsible.

Keywords: Neem, Clove, Minimum Inhibitory Concentration, Zone of Inhibition.


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