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Abstract

DUAL WAVELENGTH SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF BENIDIPINE HYDROCHLORIDE AND TELMISARTAN IN PHARMACEUTICAL DOSAGE FORM

Khyati Patel*, Darshil Shah and Dr. Dilip Maheshwari

ABSTRACT

The present manuscript describes simple, sensitive, rapid, accurate, precise and cost effective dual wavelength spectrophotometric method for the simultaneous determination of Benidipine HCl(BEN) and Telmisartan(TEL) in combined tablet dosage form. The utility of dual wavelength data processing program is its ability to calculate unknown concentration of components of interest in a mixture containing an interfering component. The principle for dual wavelength method is ―the absorbance difference between two points on the mixture spectra is directly proportional to the concentration of the component of interest. The method was based on determination of Benidipine HCl at the absorbance difference between 228.36nm and 245.39nm and Telmisartan at the absorbance difference between 280.21 nm and 315.39 nm. The linearity was obtained in the concentration range of 1-5 μg/ml for Benidipine HCl and 10-50 μg/ml for Telmisartan. The accuracy and precision of the method was determined and validated statically. The method showed good reproducibility and recovery with % RSD less than 2. Method was found to be rapid, specific, precise and accurate, can be successfully applied for the routine analysis of Benidipine HCl and Telmisartan in bulk, and combined dosage form without any interference by the excipients. The method was validated according to ICH guidelines.

Keywords: Benidipine HCl(BEN) and Telmisartan(TEL).


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