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Abstract

A REVIEW ON CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF OPIPRAMOL DIHYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM

Purvangi S. Patel* and Dr. Dilip G. Maheshwari

ABSTRACT

Opipramol dihydrochloride is an Antidepressantand Anxiolytic
drug. It is a member of the tricyclic antidepressants, opipramol's
primary mechanism of actionis much different in comparison. Most
TCAs act as reuptake inhibitors, but opipramol dihydrochloride does
not, and instead acts as a sigma receptor agonist. This is generally
administered as tablet dosage form. Mostly the work is done on RPHPLC
with different methods and for its estimation the mobile phase
used are usually the same that are in different ratio of Acetonitrile and
Potassium Dihydrogen Orthophosphate. This review entails the
different methods for estimation of Opipramol dihydrochloride like
UV, HPTLC, HPLC, LC.

Keywords: Opipramol dihydrochloride, Antidepressant, stability indicating method, UVspectroscopy, HPLC (High Performance Liquid Chromatography), HPTLC (High Performance Thin Layer Chromatography), LC (Liquid Chromatography).


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