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Abstract

A REVIEW ON CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF RIVAROXABAN AND TICAGRELOR

Ayushi R. Mehta* and Dr. Dilip G. Maheshwari

ABSTRACT

RIVAROXABAN is a drug which belongs to class of anticoagulant.
Rivaroxaban is approved for the prevention of strokes and systemic
embolism in atrial fibrillation. It is useful in prevention blood clot and
treatment of deep venous thrombosis. TICAGRELOR is a platelet
aggregation inhibitor which is an antagonist of the P2Y12 receptor of
thrombotic events in acute coronary syndrome or myocardial infarction
with ST elevation Combination of Rivaroxaban and Ticagrelor was
Proved to be effective in Atrial fibrillation compare to Rivaroxaban
and Ticagrelor monotherapy. This review entails different method
developed for determination of the Rivaroxaban and Ticagrelor like
UV-spectroscopy, liquid chromatography, HPTLC and HPLC.

Keywords: Rivaroxaban, Ticagrelor, UV- Spectroscopy, HPLC (High Performance Liquid Chromatography), HPTLC (High Performance Thin Layer Chromatography), LC (Liquid Chromatography).


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