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Abstract

VALIDATION OF FLUIDIZED BED DRYER

V.P. Pandey, Srikanth.Paturi, A.G. Joshi and H.L.N. Rao

ABSTRACT

The present study is undertaken to validate pharmaceutical equipment, fluidized bed dryer (FBD), for ensuring quality products as well as processes. After study of design qualification (DQ), installation qualification (IQ), Operational qualification (OQ) and performance qualification (PQ), it is found that machine is working satisfactorily and its design and drawing reveal that the machine is according to the order of the company. The drug chosen for this study is cephalexin and it is observed that steam heating is more efficient than heat banks. It is found that as the drying time increases, the percentage of fines in the granules get increased. So shorter drying time will produce desired granules with fewer fines.

Keywords: fluidized bed dryer, cephalexin.


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