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Balu Mahendran.K, Santhosh Kumar.N, Kalaivanam K.N, R.Bheemasen


Alcoholic liver disease (ALD) is an alcohol induced disease with multiple factors influencing its development and manifestations. It is proposed that alcohol ingestion produces metabolic imbalances in liver leading to increased formation of reactive oxygen species and decreased levels of antioxidants. The study intends to understand the mechanism of the disease by evaluating the role of lipid peroxidation and antioxidant status in the patients of ALD. The present study involved 40 participants of which 20 were patients admitted with diagnosis of ALD and other 20 were age and sex matched healthy controls who fulfilled inclusion criteria. In ALD patients compared to controls significant increase in following parameters was observed. Malondialdehyde and uric acid are significantly increasedcompared to controls (P<0.001), total bilirubin and the direct bilirubin also increased significantly (P<0.001). The levels of AST, ALT and AST/ALT ratio, ALP and GGT were significantly increased (P<0.001). The levels of vitamin C, total protein and albumin were significantly reduced in patients with alcoholic liver disease compared to controls with P<0.05 and P<0.001 respectively. ALD is due to increased oxidative stress and decrease of antioxidants. Malondialdehyde a lipid peroxidation product is a sensitive marker of ALD and its severity.

Keywords: Alcoholic liver disease; Malondialdehyde, lipid peroxidation, Vitamin C, Reactive Oxygen Species (ROS).

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