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Abstract

A LATEST REVIEW ON LIQUISOLID TECHNIQUE AS A NOVEL APPROACH

D.Lohithasu, J. V.Ramana., P.Girish , I.N.S. Harsha,G.Madhu4,K.Lavanya and D.Swathi Sri

ABSTRACT

The bioavailability and solubility were major challenge for the pharmaceutical industry with developments of new pharmaceuticals. The liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. Generally, Watermiscible organic solvent systems with high boiling point like propylene glycol, polyethylene glycols, or glycerine are used as liquid vehicles for improved wettability and ensures molecular dispersion of drug in the formulation and leads to enhance solubility in liquisolid technique. When the carrier is saturated with liquid, a liquid layer is formed on the particle surface which is instantly adsorbed by the fine coating particles forming a dry, free flowing and compressible powder. Generally, Micro Crystalline Cellulose is used as carrier and silicon dioxide as coating material in liquisolid technique. Liquisolid compacts of poorly soluble drugs containing a drug solution or drug suspension in a solubilising vehicle show enhanced drug release with increased surface area of drug release, increased aqueous solubility and improved wettability of the drug particles. There are various methods but liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. In liquisolid technique, suspension and solution of solid drugs in non-volatile solvent systems and liquid drug convert into solid dosage form by using carriers and coating materials. Liquisolid system is characterized by flow behaviour pattern, wettability, powder bed hydrophilicity, saturation solubility, drug content, differential scanning calorimetry, Fourier transform infra red spectroscopy, powder X-ray diffraction, scanning electron microscopy, in-vitro release and in-vivo evaluation. By applying this novel and capable technique, solubility and dissolution rate can be enhanced, sustained drug delivery systems be developed for the water soluble drugs. It contains liquid medications in powdered form. This technique is an efficient method for formulating water insoluble and water soluble drugs.

Keywords: Liquisolid technology, Free flowing, and Wettability.


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