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Abstract

EVALUATION OF PHYTOCHEMICAL, ANTIBACTERIAL AND ANTIDIARRHOEL ACTIVITY OF JATROPHA GOSSYPIFOLIA L. ROOT METHANOL EXTRACT IN SWISS ALBINO MICE

Rani B. Bhagat, and D. K. Kulkarni

ABSTRACT

The roots of J. gossypifolia used for treatment of diarrhoea, dysentery, inflammation in ethno-medicinal practices. Qualitative and quantitative phytochemical analysis showed presence of secondary metabolites like-alkaloids, Phenols, flavonoids, tannins etc. The root was undertaken to study antidiarrhoeal activity using suitable animal models. Root powder was successively extracted with petroleum ether, methanol and distilled water. Solvents from these extract were removed under reduced temperature and pressure. Exploratory studies revealed presence of significant antidiarrhoeal activity only to methanol extract. This extract was studied using suitable tests consisting of castor oil and magnesium sulphate induced diarrhoea and barium chloride induced peristalsis using Swiss albino mice. The in vitro antimicrobial activity against micro-organisms also showed potent activity. Extract showed action against castor oil, magnesium sulphate induced diarrhoea and enteropooling activity due to castor oil treatment as well as on normal and barium chloride induced peristalsis of small intestine significantly in mice, so also antimicrobial activity against common pathogens responsible for diarrhoea in vitro. The results of above investigations are supporting the ethno-medicinal use of J. gossypifolia root for the treatment of diarrhoea.

Keywords: Jatropha gossypifolia; Phytochemical; TLC/HPTLC; Antimicrobial; Antidiarrhoeal; Swiss albino mice.


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