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Abstract

SYNTHESIS OF PHARMACOLOGICAL ACTIVE 8-[2/-(3//, 5//- DIMETHYL-4//-ETHOXY CARBONYL PYRROLYL) HYDRAZINE] SUBSTITUTED PHENOTHIAZINES DERIVATIVES

Dr. Meghasham N. Narule

ABSTRACT

Phenothiazine derivatives substituted in the 2, 3 and 4 positions belong to a big group of tricyclic aromatic compounds. They are in extensive use in psychiatry as tranquilizers and neuroleptics. Due to their characteristic structure they exhibit many valuable analytical properties. A short facile synthesis of 8-[2/-(3//, 5//-dimethyl-4//- ethoxy carbonyl pyrrolyl) hydrazine] substituted phenothiazines (5a-j) from 2-arylamin benzal-2-(3′,5′-dimethyl-4′-ethoxy carbonyl pyrrole)hydrazines (4) in presence of sulphur and iodine. These compounds were screened for their antibacterial activity against S. aureus and E. coli as well as for their antifungal activity against C. albicans and A. niger. The synthesized compounds are characterized by FTIR, 1H NMR, elemental and chemical properties.

Keywords: Pharmacological active, pyrrolyl, phenothiazines.


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