Abstract

BLOOD HYPEREOSINOPHILIA REVELING ADENOCARCINOMA WITH REARRAGEMENT ROS 1: A CASE REPORT

Rasoafaranirina Marie Odette*, Ravahatra Kiady, Rakotoarisoa Oninalafenitra, Martin Fidy Arnauld, Nandimbiniaina Anjaramihaja, Rakotondrabe Iantsotiana Davidson, Tiaray Harison Michel, Rakotomahenina Hajanirina, Rakotomizao Jocelyn Robert, Goutorbe Frederic, Rakotoson Joelson Lovaniaina and Raharimanana Rondro Nirina

Abstract

Lung cancer, like other solid tumors, is a rare cause of hypereosinophilia. We report a case of a young, non-smoking, 38-year-old woman presenting with a rare case of cancer "a pulmonary adenocarcinoma with ROS1 rearrangement associated with blood hyperosinophilia". Clinical presentation was marked by acute respiratory distress on right pleural effusion of great abundance. The diagnosis was obtained during a thoracoscopy. The evolution with crizotinib was spectacular with normalization of blood eosinophil level after five days of treatment. Lung cancer is one of the rare causes of blood eosinophilia.

Keywords: Paraneoplastic hypereosinophilia, lung adenocarcinoma, ROS 1.