Abstract

PHYTOCHEMICAL SCREENING AND PHARMACOLOGICAL STUDIES WITH ANGIOPTERIS EVECTA ROOTS

Md. Forhad Molla, Shahnaz Rahman, A.B.M. Anwarul Bashar,*Mohammed Rahmatullah

Abstract

Objective: The objective of the present study was to phytochemically screen and evaluate the antihyperglycemic and analgesic potential of methanolic extract of Angiopteris evecta roots. Methods: Extract was administered orally at doses of 50-400 mg/kg. Oral glucose tolerance test (OGTT) was used to evaluate antihyperglycemic activity in glucose-loaded mice. Analgesic activity was assessed in intraperitoneally injected acetic acid-induced pain model. Results: The extract, at doses of 50, 100, 200, and 400 mg/kg, reduced blood glucose levels by 11.3, 23.0, 32.8, and 46.7%, respectively. By comparison, a standard antihyperglycemic drug, glibenclamide (10 mg/kg) reduced blood glucose levels by 47.4%. In acetic acid-induced pain model, the extract reduced the number of abdominal constrictions by 25.9, 40.7, 48.1, and 59.3%, respectively, at doses of 50, 100, 200 and 400 mg/kg. A standard analgesic drug, aspirin (200 and 400 mg/kg) reduced abdominal constrictions by 48.1 and 63.0%, respectively. Conclusion: The extract possesses significant antihyperglycemic and analgesic potential.

Keywords: Angiopteris evecta, Marratiaceae, antihyperglycemic, analgesic, oral glucose tolerance, glibenclamide.