Abstract

SYNTHESIS AND CHARACTERIZATION ANTIBACTERIAL ACTIVITY OF NOVEL LIGAND-2, 6-DIAMINOPYRIDINE-2-ACETYL- 5-CHLOROTHIOPHENE AND ITS METAL (II) COMPLEXES

Dr.Mohammed.Fakruddin Ali Ahamed, 2Dr. Venkatesan Jayakumar,Sileshi Tolera Goshu.

Abstract

The biologically active Schiff base (imines) was synthesized by thereaction of 2, 6-Diaminopyridine-2-acetyl-5-chloro thiophene in thepresence of conc. Acid. The characterization of Schiff bases werecarried out by using elemental analysis and VSM including FT-IR, 1HNMR, 13C NMR analyses. The Schiff bases were checked forbiological screening and found that the compound with -SH group tobe more biologically active than the compound with halo (-X) groupJob’s continuous variation method and Mole ratio method revealed 1:1metal to ligand ratio, by chelation of metals Zn (II) with Penta-dentatecomplexes were synthesized.

Keywords: Penta-dentate Schiff base, 2, 6- Diaminopyridine-2-acetyl-5-chloro thiophene, Biological activity.