Abstract

SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL (E)-N'-BENZYLIDENE- 3-(PIPERAZIN-1-YL)BENZO[B]THIOPHENE-2-CARBOHYDRAZIDE DERIVATIVES

Kushal Bansal, Prabodh Chander Sharma, Rajeev Kharb*

Abstract

A novel series of (E)-N'-benzylidene-3-(piperazin-1- yl)benzo[b]thiophene-2-carbohydrazide derivatives (5a-5l) were synthesised from the starting materials like cinnamic acid, thionyl chloride, chlorobenzene and pyridine resulting in synthesis of 3- Chlorobenzo(b)thiophene-2-carbonyl chlorides which were further reacted with hydrazine hydrate, aromatic aldehydes and finally with substituted piperazines to yield the titled compounds. Structural characterization of the synthesized compounds was carried out by instrumental method of analysis like IR, 1H-NMR and Mass spectroscopy. The titled compounds were subjected to in-vitro antibacterial activity against bacteria E. coli and S. aureus and antifungal activity against fungi C. albicans. The biological results indicated that compound 5l showed most potent antibacterial activity and 5c displayed most potent antifungal activity on comparision with Ciprofloxacin and Fluconazole as respective standard drugs.

Keywords: Benzothiophene, Piperazine, antibacterial, antifungal activity.