Abstract

TO STUDY THE EFFECT OF 5-HT1A ANALOGUES, 8-OH-DPAT AND WAY 100635 IN ANXIETY

Mrs. Hina D. Mehta*, Dr. Narendra R. Dighade

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Abstract

Present work constitutes an evaluatory role of serotonin receptors using its analogues by administering to CeA in ethanol-induced anxiolysis, tolerance to ethanol anxiolysis using elevated plus maze (EPM) paradigm in rats. Ethanol was injected intraperitoneally (i.p.) with exception of ketamine and xylazine that was given by intramuscular (i.m.) route. Ethanol was diluted with 0.9% saline to a concentration of 8% w/v for i.p. injection or to 6% v/v in a liquid diet for oral chronic consumption. 5-HT1A serotonin receptor analogues will be injected by intra central nucleus of amygdala (i.CeA.) administration except p-CPA injected by i.p route. Prolonged ethanol (alcohol) consumption leads to the development of tolerance and dependence.

Keywords: Ethanol, 5-HT1A Serotonin analogue, EPM, Tolerance.