Abstract

FORMULATION & DEVELOPMENT OF GASTRORETENTIVE MUCOADHESIVE TABLETS OF ANTIDIABETIC DRUG USING NATURAL POLYMERS

Ravi Kumar*, Priyanka Rathore, Durga Pandey and RB Goswami

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Abstract

Gliclazide has been widely used for the treatment of Diabetes Mellitus. However, due to being extensively metabolized in the liver and its metabolites have no significant hypoglycemic activity, frequent dosing is required and shows several ADRs. Hence, the present investigation was concluded with an attempt to design and optimize GMDDS of Gliclazide using natural polymers like chitosan, xanthan gum, and moringa gum. The present research aimed to prepare mucoadhesive tablets using natural gums using the direct compression method. Three batches of preliminary formulations were prepared and from the results of evaluations, final formulations were selected for further study by using natural polymers. Further development of mucoadhesive tablets was made by using combinations of natural gums. All final formulations were evaluated for flow properties, hardness, friability, weight variation, drug content uniformity, in-vitro swelling studies, and in-vitro drug release pattern. Stability studies of optimized formulation (F9 & F10) were done for one month and results suggested that formulations show no significant changes in drug content and in-vitro drug release study. The study concluded that gliclazide GMDDS formulation using natural gum can effectively improve bioavailability and sustained release can be obtained.

Keywords: GMDDS, Diabetes Mellitus, Gliclazide, Natural gums, in-vitro drug release study, & swelling index.