Abstract

A REVIEW ARTICLE ON THE PROCESS AND DEVELOPMENT OF NEW DRUG DOSAGE FORM

Prof. Dr. Mohd Wasiullah, Piyush Yadav*, Vishwakarma Kajal and Satish Kumar Yadav

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Abstract

Preformulation is a group of studies that focus on the physicochemical properties of a new drug candidate that could affect the drug performance and the development of a dosage form. This could provide important information for formulation design or support the need for molecular modification. Every drug has intrinsic chemical and physical properties which has been consider before development of pharmaceutical formulation. This property provides the framework for drugs combination with pharmaceutical ingredients in the fabrication of dosage form. Objective of Preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic rate profile, compatibility with the other ingredients and establish Physico-chemical parameter of new drug substances. Among these properties, drug solubility, partition coefficient, dissolution rate, polymorphic forms and stability are plays important role in Preformulation study. Polymorphism having crystal and amorphous forms shows different chemical physical and therapeutic description of the drug molecule. This article explains some properties and techniques for Preformulation evaluation parameters of drug.

Keywords: Preformulation, Partition coefficient, Dissolution-Rate, Polymorphic.