Abstract

A REVIEW ON CURRENT TRENDS AND NOVEL DRUG APPROACH IN THE TREATMENT OF HYPERTENSION

A. R. Shabaraya and M. Reshma*

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Abstract

Hypertension is one of the most significant public health challenges and is regarded as the primary cause of the global burden of disease. It is a major contributor to the risk of coronary heart disease, stroke, and chronic kidney disease. Effective hypertension management will undoubtedly have one of the biggest contributions to saving lives in the upcoming years. Regular blood pressure measurements are necessary due to the asymptomatic nature of hypertension and the medical impact it carries. Due to intolerance to the existing antihypertensive medications, a large number of hypertensive patients remain uncontrolled. Hence, new therapeutic targets and treatments are required to control hypertension and may provide additional BPlowering with broader cardiovascular disease protection. In comparison to current medications, several novel drugs have demonstrated greater safety and efficacy in clinical studies and may end up being a preferable alternative due to minimal adverse effects and the prevention of end-organ damage. The process of development of a drug is a tedious, complex, and expensive process, entrenched with a high degree of uncertainty that a drug will actually succeed. Prioritizing BP reduction with the use of appropriate and individualized dosages of current drugs will continue to be a crucial goal in the management of hypertension until new technology is ready for practical usage.

Keywords: Novel drug, Hypertension, Blood pressure, Current trends.