Abstract

DISSOLUTION ENHANCEMENT OF LAMOTRIGINE

*Thillaikarasan S., Ganesh Meena B., Oviya K., Dhaya K., Abdul Hasseeb M. S., Jeevanatham S. and Gokul Manikandan P.

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Abstract

Enhancing the dissolution by formulating a Mouth Dissolving Film of Lamotrigine and Invitro evaluation of Mouth Dissolving Film, Comparative study of Invitro dissolution studies between the formulated Mouth Dissolving marketed immediate release tablet formulation. Formulation of mouth dissolving film by solvent casting method using Gellan gum as Film forming polymer, Glycerine as Plasticizer and Microcrystalline cellulose as Super disintegrant, Aspartame as Sweetening agent, Citric acid as Saliva stimulating agent. The formulated mouth dissolving films were evaluated for dissolution and disintegration studies and compared with conventional tablet formulations and gave satisfactory results of enhanced dissolution.

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