Abstract

ANALGESIC ACTIVITY OF SOLENOSTEMMA ARGEL BY MODULATING PAIN NOCICEPTION PATHWAY IN MICE

*Mahmoud M. E. Mudawi, Vijay R Chidrawar, Abdelhadi Y.A. Yassin, Rami S. Habeballa, Mohammed F. Abd E l-wahab, Mansour I. Sulaiman

Abstract

The present study aims to investigate the centrally and peripherally acting analgesic activity of the aqueous extract of Solenostemma argel (AESA) in mice by using Eddy’s Hot plate and acetic acid induced writhing model respectively. The extract was administered per orally at dose of 10 ml/kg and 20 ml/kg while diclofenac sodium was used as standard for both the models. In hot-plate model, the AESA exhibited significant analgesic activity by increasing the reaction time compared to distilled water treated group. Diclofenac Sodium considered as a mild analgesic and showed analgesic effect but not significantly in this study. In comparison with control group 20 ml/kg AESA has shown most significant (P

Keywords: Solenostemma argel, nociception, hot plate, acetic acid, phytochemistry.