Abstract

ETHOSOME: A NOVEL VESICULAR DRUG DELIVERY SYSTEM

Vishakha Doke*, Divya Kelan, Deepika Khadse, Nilesh Khutle, Yogesh Chaudhari

Abstract

Vesicular system improves therapeutic efficacies of drug by controlling and sustained action. Ethosome transport drug to the deep skin layers or systemic circulation. Ethosomes are novel carrier system used for delivery of drugs having low penetration through the biological membrane mainly skin. Ethosomes have higher penetration rate through the skin as compared to liposomes hence these can be used widely in place of liposomes. Although, the exact mechanism for better permeation into deeper skin layers from ethosomes is still not clear. The synergistic effects of combination of phospholipids and high concentration of ethanol in Vesicular formulations have been suggested to be responsible for deeper distribution and penetration in the skin lipid bilayers. The size range of ethosomes may vary from tens of nanometers to microns. This review focused on ethosome, its method of preparation, mechanism of action, its characterization and applications.

Keywords: Vesicular system, Ehosomes, Liposomes, Phospholipids.