Abstract

EVALUATION OF THE EFFICACY OF HERBAL BASED FORMULATION IN PATIENTS OF HEART FAILURE

Dr. Savitri Vasudev Baikampady*

Abstract

T AYU BKV is a new positive inotrope with a unique mechanism of action. To assess its clinical utility we administered this tablet of 125mg twice a day along with meals (250mg/day) for 90 days to 100 patients with Left Ventricular Ejection fraction less than or equal to 50% and also who had substantial limitations in exercise performance despite treatment with conventional Heart Failure Therapy (HFT). Patients were evaluated by 2D Echocardiogram along with measurements of distance walked during six minutes Hall walk testing. Improvements were demonstrated in both, Left Ventricular Ejection Fraction and distance walked successfully after 90 days of treatment with T AYU BKV. Furthermore T AYU BKV significantly reduced Left ventricular internal dimensions at systole as well as at diastole in HF patients. However, dimensions of enlarged Left Atrium were compromised with a marginal decrease. Various statistical data confirms improvements in NYHA functional class along with enhancement in Quality of life (QOL). Results suggest that efficacy of this drug is warranted when used as an add-on therapy along with the conventional.

Keywords: Heart Failure Therapy, inotrope, Left Ventricular Ejection Fraction, Systole, Diastole, Left Atrium.