Abstract

FORMULATION AND CHARACTERIZATION OF FAST DISSOLVING TABLETS OF MOSAPRIDE CITRATE BY USING SUBLIMATION TECHNIQUE

B.Sudhakar*, N.Sujatha and Ramya Sri Sura

Abstract

Fast dissolving drug delivery is rapidly gaining acceptance as an important new drug delivery technology. The aim the study was to prepare and characterize fast dissolving tablets(FDT) of Mosapride citrate (a water insoluble drug and belongs to BCS class-II) by employing different technologies like liquidsolid by improving wetting, sublimation by creating porous environment, effervescent and super disintegrant by breaking the tablet fast. The FDT of Mosapride citrate was also prepared by adopting direct compression method. Physicochemical properties and in vitro release studies were evaluated. The Mosapride citrate FDTs of effervescent technology was showing immediate release with T90 % within 4 min and hence the effervescent technology was proved to be the promising in comparison with other technology types. By using invitro drug release data, it was found that FDTs of Mosapride citrate are following First order kinetics.

Keywords: Mosapride citrate, liquid solid, sublimation, effervescent, super disintegrant. FDT.