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World Journal of Pharmaceutical Research

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An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

Q-ABSORBANCE RATIO METHOD FOR SIMULTANEOUS ESTIMATION OF CILOSTAZOL AND IMIPRAMINE IN COMBINED DOSAGE FORM

Paras M. Brahmbhatt*, Laxman M. Prajapati, Amit K. Joshi, Mohammadali L. Kharodiya

Abstract

The present manuscript describes simple, sensitive, accurate, preciseand economical Q-absorbance ratio method for the determination ofcilostazol and imipramine in combined dosage form. Absorbance ratiomethod uses the ratio of absorbances at selected wavelengths, onewhich is an isoabsorptive point and other being the λ-max of one of thetwo components. Cilostazol and imipramine show an isoabsorptiepoint at 233.400 nm in methanol. The second wavelength used is 258nm, which is the λ-max of cilostazol in methanol. The linearity wasobtained in the concentration range of 10-35 μg/ml for cilostazol andimipramine.

Keywords: Cilostazol, imipramine, absorbance ratio method, isoabsorptive point, simultaneous

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