Abstract

HOT MELT EXTRUSION: PROCESS PARTS ASPECTS AND KOLLIPHOR USES

Tushar Khade*

Abstract

Originally adapted from the plastics industry, the use of hotmelt extrusion has gained favor in drug delivery applications both in academia and the pharmaceutical industry. Several commercial products made by hot-melt extrusion have been approved by the FDA, demonstrating its commercial feasibility for pharmaceutical processing. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. This review provides discussion of the formulation and processing aspects of hotmelt extrusion. This Review article mainly focus on the parts- Extruder and techniques used in Hot Melt Extrusion. This Review article also focuses on use of Kolliphor in Hot Melt Extrusion and their‟s different types.

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