Abstract

NEW PIPERAZINE DERIVATIVES: DESIGN, SYNTHESIS, AND MOLECULAR DOCKING ANALYSIS AS POSSIBLE ANTIMICROBIAL DRUGS

Md. Afaque*, Kuldeep Singh, Syed Misbahul Hasan, Saddam Hussain, Md. Rahat Raza, Md Quamar Niyaz

Abstract

Purpose: Formulation and analysis of antimicrobial effectiveness of new heterocyclic compounds containing 1-(4- fluorophenyl) piperazine derivatives. Aim: The piperazine moiety is an important nucleus for several biological functions, particularly against microbes, the research is envisaged to synthesize some novel piperazine derivatives and carry out their antimicrobial activity. Therefore, the purpose of this research is to design a novel piperazine derivatives as antimicrobial agents. Methods: Piperazine derivatives synthesized by the reaction of of When ethylenediamine and bromo-phenyl acetic acid ethyl ester react, 2-phenyl piperazine is produced. Intermediate compound of 3-phenyl-piperazin-2- one. This intermediate compound further reduction in thepresence of lithium Aluminum hydride to obtained 2- phenylpiperazine. The intermediate compounds 1a were produced through the 1-(4- fluorophenyl) piperazine reaction with bromoacetyl acetyl chloride in the presence of potassium carbonate and intermediate compounds 1b, 1c & 1d were synthesized by the reaction of different sulfonamide derivatives. Intermediate 1a react with Sulfanilic acid to form Benzenesulfonic acid The amino acid Piperazin-1-yl)-2-oxoethyl 4-((2-(4-(4- fluorophenyl)) (A2). Where intermediate 1b, 1c & 1d react with 1-(4-fluorophenyl) piperazine to form A1, A3 & A4. They were then pharmacologically evaluated for the antimicrobial activity by cup-plate method.

Keywords: Piperazine, Sulphonamide, Antibacterial, Escherichia Coli, Bacillus subtilis and Staphylococcus aureus.