Abstract

FORMULATION AND EVALUATION OF TAZAROTENE TRANSDERMAL PATCHES BY USING DIFFERENT POLYMERS

Surohitha V.*, Nazma V., Tahira Y., Kavitha C., Gowri C.

Abstract

The aim of the study is to develop and evaluate a transdermal patch of tazarotene for the treatment of psoriasis. Tazarotene is a topical retinoid used in the management of psoriasis by regulating keratinocyte differentiation and reducing inflammation. The transdermal patch of tazarotene was prepared by the solvent casting method using HPMC, ethyl cellulose, poly vinyl pyrrolidine (PVP), and glycerine, dissolving the drug in a minimal amount of water and ethanol. The prepared transdermal patch was designed to provide controlled drug release over a period of 12 hours. The patches were evaluated for physical appearance, surface morphology, thickness, weight variation, drug content uniformity, pH, and in vitro drug release studies. Among the different polymeric combinations, the formulation containing HPMC, glycerine, PVP showed maximum drug release of 92% compared to other formulations. Thus, the developed tazarotene transdermal patch may be a promising system for the effective management of psoriasis.

Keywords: Tazarotene, Psoriasis, Transdermal patch, HPMC, Poly vinyl pyrrolidine (PVP), Ethanol, Glycerine, Ethyl cellulose, Controlled drug release.