Abstract

REVIEW ON FLOATING DRUG DELIVERY SYSTEM FOR GASTRIC RETENTION

Mr. Ankush Anjana, *Mrs. Anjali Peter

Abstract

The oral route is the most widely accepted method for drug administration due to its convenience and patient compliance. However, it faces significant challenges such as rapid gastric emptying and poor absorption of drugs with a narrow absorption window in the upper gastrointestinal tract. These limitations result in reduced bioavailability and inconsistent therapeutic outcomes. To address these issues, Gastroretentive Drug Delivery Systems (GRDDS) have been developed, among which Floating Drug Delivery Systems (FDDS) are considered highly effective. FDDS are designed to have a density lower than gastric fluid, enabling them to float and remain in the stomach for an extended period. This review discusses the mechanism, classification, formulation components, evaluation parameters, and pharmaceutical applications of FDDS. These systems improve drug bioavailability, provide sustained release, and enhance therapeutic efficiency.

Keywords: Floating Drug Delivery System (FDDS), Gastroretentive Drug Delivery System (GRDDS), Gastric retention, Buoyancy, Controlled drug release, Bioavailability enhancement, Floating lag time, Hydrocolloids, Effervescent systems, Non-effervescent systems, Narrow