Abstract

INHIBITORY CAPACITY OF XANTHINE OXIDASE OF COMPOUNDS FROM ROOTS OF THE BOEHMERIA NIVEA (L.) GAUDICH

Thi-Ngoc Lanh, Thi-Lan Dinh, Quang-Ung Le*

Abstract

The roots of Boehmeria Nivea (L.) Gaudich is used to treat rheumatoid arthritis in Vietnam. The evaluation of the xanthine oxidase inhibitory capacity of compounds and root extracts was firstly studied in this work. Two compounds of (+)- isolariciresinol and gingerglycolipid A were identified in the roots. The EtOAc fraction exhibited the highest xanthine oxidase inhibitory activity compared to the n-hexan and water fractions. The capacity of xanthine oxidase enzyme inhibitory was detected from (+)-Isolariciresinol, Gingerglycolipid A and E70, with IC50 of 6.46 ± 0.22; 14.32 ± 0.36; 31.66 ± 0.13 μg/ml, respectively. The present work suggested that Boehmeria Nivea (L.) Gaudich could be a precious herb for gout patients.

Keywords: Boehmeria Nivea, enzyme xanthine oxidase, gout.