Abstract

SELENIUM NANOPARTICLE IN CHRONIC WOUND MANAGEMENT: MECHANISM AND ITS BIOMEDICAL APPLICATIONS

Lakshay Gupta, Deepika Rani*, Bhartendu Sharma

Abstract

For the intended delivery, selenium nanoparticles (SeNPs) may be a desirable delivery method. The potential for selenium nanoparticles to treat a variety of conditions, including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), asthma, liver, and other autoimmune disorders like psoriasis, cancer, diabetes, and numerous infectious diseases, is what has drawn them to the world. However, there is currently no recent literature that summarizes the therapeutic applications of SeNPs. The identification of SeNP targets in various diseases and the various functionalization techniques used to guarantee that SeNPs remain stable, can be readily transported to the tumor regions, and prevent undesirableIn order to comprehend the science underlying off-target effects, it is important to learn more about the therapeutic features. With that in mind, we have focused on this gap and made an effort to summarize the vast array of functionalization techniques as well as all the recent noteworthy targeted therapies of SeNPs in cancer treatment. Additionally, we have focused on the latest advancements in biomedical application mechanisms and SeNP functionalization techniques, particularly with regard to anticancer, anti-inflammatory, and anti-infection therapies According to our observations, SeNPs may be used in addition to their antibacterial and antiparasitic properties to decrease viral epidemics like the current COVID-19 pandemic. SeNPs are noteworthy nanoplatforms with a variety of desired clinical translation characteristics.

Keywords: Selenium nanoparticles,anti-inflammatory, cancer therapy, antiviral activity, antiparasitic activity..