Abstract

CYCLODEXTRINS IN COSMETIC FORMULATIONS: EMERGING ROLE AS SOLUBILITY ENHANCERS, STABILIZERS AND FUNCTIONAL CARRIERS

*Astha Dahekar, Dr. Sonal Dhabekar

Abstract

Cyclodextrins (CDs) have been known for over a century, yet their relevance in formulation science continues to expand. In both pharmaceutical and cosmetic applications, these molecules are valued for their ability to interact with hydrophobic compounds and form inclusion complexes. In the context of cosmetic formulations, this property becomes particularly useful when dealing with ingredients that show limited solubility in water. Over time, cyclodextrins have been increasingly explored not only for improving solubility, but also for enhancing the stability and availability of active ingredients on the skin. This review discusses their structural features, the mechanism of inclusion complex formation, and their practical role in cosmetic systems. Particular attention is given to their use as solubility enhancers for compounds such as vitamins, essential oils, and UV filters, which are otherwise difficult to formulate. In addition, their contribution to fragrance stabilization, controlled release behavior, and overall skin compatibility is considered. Safety aspects, regulatory considerations, and emerging trends in cosmeceutical applications are also briefly addressed to provide a more complete perspective.

Keywords: Cyclodextrins, inclusion complex, solubility enhancement, cosmetic formulation, controlled release, cosmeceuticals.