Abstract

TRANSFEROSOMES: A NOVEL APPROACH TO DELIVER OF MICONAZOLE NITRATE FOR TOPICAL PREPRATION

Vijay Belwal*, Manoj Bhardwaj and Dinesh Kumar Sharma

Abstract

Transferosome of Miconazole nitrate were formulated and evaluated to improve the permeability, site specificity and retention time of the miconazole nitrate with specific emphasis on bioavailability enhancement. Transferosome of miconazole nitrate were prepared by using a various variable parameters like Phospholipids (Soya phosphatidylcholine) in the ratio of 400:450:500:600:650 , surfactants 3.5:1:1.5:2:2.5 and Organic solvents in the ratio of 1:2. Transferosome of miconazole nitrate for different formulations (T1, T2, T3, T4 and T5) were evaluated by particle size, particle morphology, pH, zeta potential, drug content, drug entrapment, and in-vitro drug release. The formulation of T2 was found to be optimized from all the formulations prepared.

Keywords: Transferosome, Topical route, Phospholipid, Surfactant, stratum corneum, invitro.