Abstract

EFFECT OF CO-ADMINISTRATION OF THE EXTRACTS OF BOUGAINVILLEA SPECTABILIS AND CATHARANTHUS ROSEUS ON PROTEIN AND GLYCOGEN CONTENTS OF DIABETIC ALBINO RATS.

Zamin Ahmad*, Masood Hussain, Rafath Yasmeen, Kaiser Jamil and Kusum Singh

Abstract

Bougainvillea spectabilis and Catharanthus roseus extracts are part of various herbal formulations for the treatment of diabetes. The present study aims to determine the biochemical alterations due to Coadministration of Bougainvillea spectabilis and Catharanthus roseus leaf extracts on female diabetic albino rats. Bougainvillea spectabilis and Catharanthus roseus leaves extracted with methanol and administered to both normal and alloxan induced diabetic rats. The protein and glycogen levels were measured at 7, 14 and 21 days at a dose level of 300 mg/kg b.wt. In the present study, effect of Methanolic extract of combination of Bougainvillea spectabilis and Catharanthus roseus in various organs of diabetic albino rats significantly increased the protein as well as glycogen content at 300mg/kg b.wt for intervals of 7, 14 and 21 days. It may be due to the presence of certain phytoconstituents of plants such as flavonoids, Saponins etc.

Keywords: Bougainvillea spectabilis, Catharanthus roseus, alloxan, protein, glycogen.