Abstract

PHYTOCHEMICAL INVESTIGATION AND ANTIDIARRHOEAL ACTIVITY OF VARIOUS LEAF EXTRACTS OF DALBERGIA SISSOO (ROXB.) IN EXPERIMENTALLY INDUCED DIARRHOEA IN MICE

*Sangram K. Panda, Ram P. Padhy, Suchismita Pani and Dibya C. Hial

Abstract

Diarrhoea has long been recognized as one of the most important health problems in the developing countries. About 80% of people in developing countries depend on traditional systems of medicine for primary health care. Dalbergia sissoo leaf has been used traditionally for the treatment of eye ailments, sore throats, heart problems, dysentery, syphilis and gonorrhea Therefore, the present study was undertaken to evaluate the antidiarrhoeal potential of D.sissoo leave extracts in castor oil induced diarrhea model. For this Swiss albino mice of either sex were used. all the crude extracts of D.sissoo leaf such as ethanol, ethyl acetate, n-butanol and petroleum ether were tested for antidiarrhoeal activity at 200 and 400 mg/kg body weight. Where as loperamide (3 mg/kg) were used as standard drugs and given orally. The pet. ether extract of D.sissoo leave was found to be effective in a dose dependent manner against castor oil induced diarrhoea on experimental mice at the dose of 400 mg/kg body weight.

Keywords: Dalbergia sissoo, antidiarrhoeal, n-butanol.