Abstract

DEVELOPMENT OF SUSTAINED RELEASE MICROPARTICLES OF DICLOFENAC SODIUM USING STEARIC ACID AS POLYMER BY EMULSION/CHILLING METHOD

Sujata Kumari, Meenu Nagpal*, Puneet Kaur, Upendra K. Jain, Akshita Dhiman and
Jyoti Choudhary

Abstract

Diclofenac Sodium was used as core using Stearic acid as polymer and Microparticles were prepared by Emulsion/Chilling method. The prepared microparticles were evaluated for Particles size, Percentage yield, Bulk & Tapped Density, Angle of Repose, Carr’s Index, Hausner Ratio, SEM, Dissolution study. All Microparticles were obtained were discrete, Small & large sized, spherical and non spherical. Diclofenac Sodium release form microparticles followed first order kinetics and influence by the size of microparticles. Slow release of Diclofenac Sodium from Stearic acid microparticles over 18 hours was observed.

Keywords: Diclofenac Sodium, Microparticles, First order kinetics.