Abstract

PHYTOCHEMICAL EVALUATION AND QUANTITATIVE ESTIMATION OF COROSOLIC AND URSOLIC ACID FROM PSIDIUM GUAJAVA

Rajkumar Diwakar*, Irfan Shaikh*, Himanshu Dawda, Usha Mukundan

Abstract

Diabetes is one of the major concerns in the twenty first century. Unhealthy lifestyles, strenuous work environments and stress are the major contributors for diabetes. Approximately 387 million people in the world, including 75 million people in India, suffer from diabetes. In addition to allopathy people are turning to traditional medicines for the treatment of diabetes. In traditional medicine there are many plants that are used to control diabetes. Some of the important plant-derived molecules for the treatment of diabetes are D-Pinitol, B-Sitosterol, Urosolic acid and Corosolic acid. Owing to the tremendous therapeutic potential of Corosolic acid and Ursolic acids they play a significant role in treatment of diabetes. Psidium guajava is a common fruiting tree cultivated mainly in tropical and subtropical regions of the world. It is used to treat different ailments in traditional medicine. The phytochemical analysis was performed using methanolic extract. HPTLC was used for quantitative estimation. The result reveals that in case of Corosolic acid, the maximum amount is present in the fruit (1.14 mg/g) followed by leaves (0.528mg/g). A comparison of the quantities of Ursolic acid shows that the maximum amount is present in outer bark (5.10mg/g) followed by leaves (5.05mg/g). Ursolic acid was not detected in the seed sample. Psidium guajava is potentially a very cost effective source of Corosolic acid and Ursolic acid for the treatment of diabetes.

Keywords: Diabetes, Urosolic acid, Corosolic acid, Psidium guajava