Abstract

SAR: SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL 5-(2-FLUORO / 2, 3-DI FLUORO PHENYL) - 1, 3, 4-THIADIAZOLE-2- AMINE DERIVATVES AS ANTI-CANCER COMPOUNDS

Sushama S. Kadam*, Dr. G. M. Nazeruddin, M. Rafique Sarkhwas and S. B. Suryawanshi

Abstract

Structure-activity relationships (SAR) are the traditional practices ofmedicinal chemistry, which try to modify the effect or the potency (i.e.activity) of bioactive chemical compounds by modifying theirchemical structure. Medicinal chemists use the techniques of chemicalsynthesis to insert new chemical groups into the biomedical compoundand test the modifications for their biological effects. The 5(2, 4-dihydroxy phenyl) 1, 3, 4, thiadiazole-2-amine’s set are well knowncompounds with interesting in vitro and in vivo anti-cancer profiles.On the basis of SAR we wish to report here with synthesis of eightnovel 5-(2-fluoro and 2, 3-difluoro phenyl)-1, 3, 4-thiadiazole-2-amineand their derivatives.They are evaluated for anti-microbial activityThey may have potential anti-cancer activity.

Keywords: Structure-activity relationships (SAR), 1, 3, 4, Thiadiazole derivatives,Anti-microbial activity, Anti-cancer activity