Abstract

ABO BLOOD GROUP POLYMORPHISMS IN ELEVEN TRIBAL POPULAIONS OF SOUTH INDIA

P. Raghu, A. Deva, R. Nandakumar*, S. Ganga and K. Prabhakaran

Abstract

Background: Southern India is one of the oldest geophysical regions of human evolution and Migration in the world. Genetic and anthropological studies have shown that the peopling the subcontinent is characterized by a complex history, with contributions from different ancestral populations. As the polymorphisms genetic level in always associated with health and disease population level studies is becoming the need of hours. Aim: This study is aimed to explore the relationship of ABO blood groups in genetic association Populations. Methods: Blood samples from 1025 unrelated individuals drawn from south India tribal settlements blood groups of individuals are ascertained with the presence of antigen using monoclonal antibody by a standard blood typing are Protocol, Gene frequencies is calculated by Hardy- Weinberg method. Results: The study populations harboused blood groups (A), (B), (O) and (AB) with the of frequencies are 23.9%, 30.1%, 38.9% and 7.02%, respectively. This occurred in the order O> B >A > AB .The allele frequency of blood group O is the highest ABO allele p (A), q (B), r (O) as 0.1688, 0.207 , 0.623, respectively. This occurred in the order O> B >A. The allele frequency of blood group O is the highest, 𝜒2 The goodness of fit test was resulted in value was = 0.001 and p value was 0.977. The genotype frequencies are reached (D) = 98.0% and (d) = 2%, genotype frequencies are (D) = 0.982 and (d) = 0.018. There is the high proportion of Rh (D) +ve individuals than the Rh - ve in the study populations. Conclusion: The present study as carried out Eleven Dravidian for Tribal groups ABO blood group polymorphisms, phenotype frequency.They suggest that O +ve individuals are accounted as the major proportion followed by B,A and AB. The results of the present study indicate that the Dravidian tribal populations share a common ancestors and a dramatro allele frequency was shown as a result of a founder effect. Data among tribal suggest their common origin as well as a drift from an original population due to the possible founder effect among tribal Dravidian Elven Tribal.

Keywords: ABO, Rh, Blood Groups, Allele Frequencies, Hardy-Weinberg, Dravidian Tribes, India.