Abstract

IN SILICO CHARACTERIZATION OF PUTATIVE DRUG TARGETS IN PASTEURELLA MULTOCIDA CAUSING FOWL CHOLERA

Gurubasappa G. Biradar, Rajeshwari D. Sanakal, Rohit B. Kaliwal, Shivasharan
C.T and Basappa B. Kaliwal*

Abstract

The present investigation deals with the in silico characterization of putative drug targets in Pasteurella multocida. The predictions of target for the drug discovery were made by using Bioinformatics tools like kyto encyclopedia in genes and genomes data base. The results showed that, 73 pathways of Pasteurella multocida retrieved from web server were found to be non homologous to the host Gallus gallus (chicken) out of which 59 pathways were found to be in cytoplasm, 3 in periplasm,1 in outer membrane and 10 are unknown. The knowledge of the present study could make the drug discovery easier which have high affinity to the target site of the causative organism. Current vaccines against fowl cholera include bacterins, which provide only limited protection against homologous serotypes and live attenuated strains, which have been observed to revert to virulence. Therefore, the present work is carried out there is a need for more effective vaccines to control diseases caused by P. multocida.

Keywords: fowl cholera, Pasteurella multocida, Phylogenetic tree, KEGG Metabolic pathway, Drug.