Abstract

UTILITY OF SUPERACID IN HETEROCYCLIC CHALCONE SYNTHESIS

Richa Kaur Bhatia*, Satyavathi Kancherla and Lakhwinder Singh

Abstract

Chalcones and chromenones (heterocycle) constitute major sub-classes of naturally occurring flavonoids. In view of their variety of pharmacological activites, it has been decided to synthesis chromenone chalcone derivatives. Therefore, chalcone condensation reaction is standardized utilizing different reaction media. In literature, most of chalcone derivatives have been synthesised in alkaline conditions by heating, whereas, chromenone ring opens in alkaline condition. Therefore, the reaction was carried out in acidic media, employing number of acids. It has been found that the reaction yield is huge when superacid viz. Perchloric acid was employed.

Keywords: Acid catalysed, Chromone, Chalcone, perchloric acid, synthesis.