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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS OF[4+2] CYCLOADDITION REACTION BY USING BASE CATALYST UNDER ULTRASONIC IRRADIATION

Pravin Chavan*, Shivaji Jadhav, Dattatraya Pansare, Mazahar Farooqui, Megha Rai

Abstract

An efficient synthesis of substituted dihydropyrimidobenzimidazoles was achieved via (4+2) one pot three-components Povarov reaction using aromatic aldehydes, 2-amino-bezamidazole and maleic anhydride under piperidine base catalysis. The discovered methodology for the preparation of substituted dihydropyrimidobenzimidazoles offers several advantages over previous methods including mild reaction conditions, easy work-up, a wide range of applicability, less time consume and products in good yields.

Keywords: Substituted dihydropyrimidobenzimidazoles, Aromatic Aldehyde, Povarov reaction, Ultra-sound irradiation.

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