Abstract

A RESEARCH OF DEVELOPMENT AND CHARACTERIZATION OF CEPHALEXIN LOW DENSITY TABLET USING RATE CONTROLING POLYMER

Mr. Shashank Chaurasiya, Rahul Saini, Dr. Vijay Nigam, Ms. Anita Devi Shivhare

Abstract

Formulation and evaluation of Gas Powered Systems of Cephalexin Tablets was carried out by performing the preformulation studies, formulation of tablets, evaluation parameters, in vitro drug release studies and stability studies. The preformulation studies of API and drug excipients compatibility studies were carried out. IR spectroscopic analysis of drug with excipients was showed that the drug was compatible with excipients which were used in the formulation. The prepared powder blend was evaluated for parameters like angle of repose, bulk density, tapped density, compressibility index and Hausner ratio. The obtained results indicated that it has good flow property for direct compression method. The prepared tablets were evaluated for hardness, weight variation, friability, assay, Swelling Index and Buoyancy Study. All these parameters were found to be within the pharmacopoeial limits. Formulation F5 was selected for drug release and stability study on the basis of appropriate results of post compression stdy. In vitro dissolution study was carried out for F-5 formulation. The drug release was found to be 97.4 % at 10 hrs and showed controlled release pattern. in vitro Buoyancy Study of formulation showed good results. The accelerated stability studies of F-5 formulation at 40oC/75% RH for a period of 3 months indicated that there was no significant change in description, drug content and in vitro dissolution profiles. Formulation showed good release results thus, results of the current study clearly indicate, Cephalexin floating tablet was a stable dosage form and a promising potential of the Cephalexin gastroretentive system as an alternative to the conventional dosage form for controlled release. However, further clinical studies are needed to assess the utility of gastroretentive Cephalexin floating formulation.

Keywords: GERD, Rabeprazole Sodium, Buffered Tablet, Fast Release Tablet.