Abstract

POLYHERBAL GEL-BASED TREATMENT FOR RHEUMATOID ARTHRITIS FORMULATION, CHARACTERIZATION, AND EVALUATION

*Safwana M. P., Prabhu V.

Abstract

Herbal plants such as Carica papaya, Tamarindus indica, Calotropis gigantean, Cardiospermum halicacabum and Cympbopogan citratus which have long been known to be a very important source of pharmaceutical properties. The study examined the anti inflammatory effect of polyherbal gel in vitro. Denaturation of proteins is the main cause of inflammation. The anti-inflammatory properties of polyherbal extract were studied at 500, 250, 100, 50 and 5 μg/mL using an albumin denaturation assay and proteinase inhibition assay. The free radical scavenging activity of polyherbal extract was evaluated by DPPH assay. The results showed that the antiinflammatory activity of a gel based polyherbal extract shows a strong inhibition value at of IC 50 53.27 μg/ml, and Proteinase 156.2 μg/ml respectively. This study provides an evidence that the polyherbal gel possesses anti- inflammatory and antioxidant activity. That can be used for the treatment of Rheumatoid arthritis.

Keywords: Polyherbal Gel-Based, anti inflammatory, and DPPH assay.