Abstract

DEVELOPMENT OF A POLYHERBAL FORMULATION FOR THE TREATMENT OF ULCERS, A NOVEL THERAPEUTIC APPROACH

Sreelakshmi D. N.*, Madharasi R.

Abstract

Herbal plants such as Musa paradisiaca leaves Moringa oleifera leaves Raphanus sativus fruit Momordica cymapalaria leaves and Sesbania grandiflora leaves which have long been known to be a very important source of pharmaceutical properties. The study examined the anti ulcers effect of polyherbal gel in vitro. Denaturation of proteins is the main cause of inflammation. The anti-inflammatory properties of polyherbal extract were studied at 500, 250, 100, 50 and 5 μg/mL using an albumin denaturation assay and proteinase inhibition assay. The free radical scavenging activity of polyherbal extract was evaluated by DPPH assay. The results showed that the anti-inflammatory activity of a gel based polyherbal extract shows a strong inhibition value at of IC50 64.89μg/ml, and. This study provides an evidence that the polyherbal gel possesses anti-inflammatory and antioxidant activity. That can be used for the treatment of Rheumatoid arthritis.

Keywords: Polyherbal formulation, anti-inflammatory, albumin denaturation and DPPH assay.