Abstract

A REVIEW ON PHYSIOCHEMICAL, PHARMACOGNOSTICAL PHARMACOLOGICAL & ANTICONVULSANT ACTIVITY OF RAUWOLFIA TETRAPHYLLA L. (APOCYNACEAE) EXTRACT IN SWISS ALBINO MICE

Dr. Bindu Rathore*, Sumit Kumar, Meraj Ali

Abstract

Objective: The present study is design to evaluate an phytochemical constituents, Pharmacognostical, pharmacological and physiochemical properties evaluation of Rauwolfia tetraphylla leaves. Rauwolfia tetraphylla is a plant, potentially applicable in Ayurveda and Unani system of medicine for treatment of various diseases. It was found that the anticonvulsant activity of this plant has not reported earlier. The present manuscript deals he ethanolic leaf extract from the plant Rauwolfia tetraphylla is used to evaluate anticonvulsant activity by using maximum electroshock seizure (MES) model and pentylenetetrazole (PTZ) induced seizure model in swiss albino mice. The ethanolic extract was also evaluated for rutin and gallic acid content by HPTLC Chromatographic studies which is found to be 15.60% and 7.81% respectively. Ethanolic leaf extract (200-600 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES). The same doses also protected animals from pentylenetetrazole-induced tonic seizures. The study demonstrates that Rauwolfia tetraphylla plant leaves has significant anticonvulsant activity. Conclusion: The results in the paper show that the Rauwolfia tetraphylla leave is a natural antioxidant and can be used for treatment of various diseases.

Keywords: Anticonvulsant activity, Rauwolfia Tetraphylla, photochemical & pharmacological studies.