Abstract

FORMULATION AND EVALUATION OF A POLYHERBAL EMULGEL FOR DUAL THERAPEUTIC ACTIVITY IN INFLAMMATION CONTROL AND WOUND HEALING

*Sayali Madhav Panmand, Ms. Kajal Bhaskar Walunj, Nisha Sandeep More, Payal Hemant Padwal

Abstract

Inflammation is an essential early phase of wound healing, but excessive or prolonged inflammation can impair granulation, re-epithelialization, and remodeling.[1,9] In chronic or infected wounds, oxidative stress and microbial burden further compromise repair, which is why modern wound therapies increasingly aim to combine anti-inflammatory, antioxidant, and antimicrobial effects in one formulation.[5,10] Wound healing is a coordinated biological process involving inflammation, proliferation, and remodeling, and persistent inflammation can delay tissue repair.[1] Topical delivery is highly suitable for local inflammatory and wound conditions because it can concentrate actives at the target site while reducing systemic exposure.[2] Emulgel is an advantageous semisolid system because it combines the solubilizing capacity of an emulsion with the favorable spreadability and patient acceptability of gel.[3] Polyherbal therapy is especially relevant in wound management because multiple phytoconstituents may act synergistically through anti-inflammatory, antioxidant, antimicrobial, and tissue-repair pathways.[4,5] This study presents a research-paper style formulation approach for a polyherbal emulgel intended for dual therapeutic activity in inflammation control and wound management. The formulation strategy is supported by prior evidence that emulgel-based systems can provide stable topical delivery, sustained release, and improved local performance.[2,6] Also Improve patient acceptability, at the site of action, and support tissue repair through combined phytochemical mechanisms.[7,8]

Keywords: Polyherbal emulgel; wound healing; inflammation control; topical drug delivery; polyherbal formulation; anti-inflammatory activity; skin permeation; semisolid dosage form.