Abstract

FORMULATION AND EVALUATE A MUCOADHESIVE BUCCAL PATCH OF PSIDIUM GUAJAVA LEAF EXTRACT FOR EFFECTIVE LOCAL DRUGS

Neeraj Kumar*, Neha Sodiyal, Shivanand M. Patil

Abstract

The present study aimed to formulate and evaluate a mucoadhesive buccal patch containing Psidium guajava (guava) leaf extract for effective local drug delivery. Buccal patches were prepared by the solvent casting method using HPMC K15 and Carbopol 940 as polymers. Three formulations (F1, F2, and F3) were developed and evaluated for thickness, weight variation, folding endurance, surface pH, swelling index, drug content, mucoadhesive strength, drug release, and stability. All formulations showed satisfactory physicochemical properties and good mucoadhesion. Formulation F3 exhibited the highest drug content (98.1%), mucoadhesive strength (29 g), and sustained drug release profile. The results indicate that guava leaf extract can be successfully incorporated into a mucoadhesive buccal patch and may serve as a promising herbal drug delivery system for the treatment of oral infections, inflammation, and ulcers.

Keywords: Psidium guajava, Buccal Patch, Mucoadhesive Drug Delivery, HPMC K15, Carbopol 940, Guava Leaf Extract, Herbal Formulation, Oral Drug Delivery.