Abstract

PREPARATION AND EVALUATION OF BENZOCAINE BUCCAL GEL FOR MOUTH ULCER

Priyanshu Shekhar, Neha Sodiyal*, Shivanand M. Patil

Abstract

The formulation and testing of a mucoadhesive buccal gel containing benzocaine for the treatment of mouth ulcers is presented. By using buccal delivery, the drug can avoid first pass metabolism by the liver and acidic degradation once absorbed into the body. Three batches (F1; F2;F3) of gels using a solvent dispersion method (neutralized after the solvent was used) were combined with two different gelling and mucoadhesive polymers (Carbopol 940 and HPMC (K4M)). Formulations produced had similar visual qualities (clear, smooth, etc.), pH (5.1 - 6.7) and spreadability, and had consistent drug quantities (theoretically, each gel contained 5% (w/w) of benzocaine). All the formulated gels also had appropriate viscosity. Also, there have been no changes compared to variations of temperature for both room and accelerated conditions over time and they have been tested as stable. To summarize, the benzocaine buccal gel products have shown excellent mucoadhesive and rheological characteristics; it has been established that they are stable, can be made in the same way each time and therefore are suitable for providing an effective pain relief system for the treatment of oral ulcerative wounds via increasing buccal residence time.

Keywords: Mucoadhesive, benzocaine, solvent dispersion method, rheological characteristics.