Abstract

A REVIEW OF PHARMACOGENOMICS AND PERSONALIZED MEDICINE

Arun Pandi S., Manoj Kumar P., Sree Nivasan V.S., Santhosh G., Arun J., Mehtaj Begum A.*

Abstract

Pharmacogenomics is a rapidly growing field that combines pharmacology and genomics to understand how genetic differences influence an individual's response to medications. Variations in genes involved in drug absorption, distribution, metabolism, excretion, and pharmacological action contribute to significant differences in therapeutic outcomes among patients. While some individuals experience optimal treatment responses, others may encounter adverse drug reactions or inadequate therapeutic effects despite receiving the same medication and dosage. Pharmacogenomics aims to address these challenges by enabling personalized treatment strategies based on genetic information. Advances in genomic technologies, including next-generation sequencing, genomewide association studies, and bioinformatics, have accelerated the discovery of clinically relevant gene–drug interactions. Personalized medicine uses this information to improve drug efficacy, reduce toxicity, optimize dosing, and enhance patient outcomes. Clinical applications are particularly evident in oncology, cardiology, psychiatry, neurology, infectious diseases, and pain management. Despite its promise, implementation faces challenges such as testing costs, infrastructure limitations, ethical concerns, data privacy issues, and inadequate clinician education. Continued research, policy development, and integration of genomic data into healthcare systems are essential for realizing the full potential of pharmacogenomics. This review summarizes the history, scientific principles, clinical applications, challenges, and future directions of pharmacogenomics and personalized medicine.

Keywords: Pharmacogenomics; Pharmacogenetics; Personalized Medicine; Precision Medicine; Genomics; Drug Response; Biomarkers; Precision Healthcare; Genetic Polymorphism.