Abstract

A REVIEW ON FORMULATION AND EVALUATION OF BUCCAL PATCHES OF METRONIDAZOLE FOR THE TREATMENT OF PERIODONTITIS

*Prachi Dukhande, Ronal Dsilva, Srushti Davari, Roshan Gamare, Ms. Manasi Mathkar

Abstract

Periodontitis is a chronic inflammatory disease affecting the supporting tissues of the teeth and is mainly caused by bacterial plaque accumulation. Conventional dosage forms used in its treatment may show limitations such as poor bioavailability, frequent dosing, and reduced patient compliance. To overcome these limitations, the present study was aimed at formulating and evaluating a buccal patch of Metronidazole for the treatment of periodontitis. Buccal drug delivery systems provide several advantages such as bypassing first-pass metabolism, improved bioavailability and ease of administration. The buccal patches were prepared by solvent casting method using Hydroxypropyl Methylcellulose (HPMC) as the polymer and glycerine as the plasticizer. Different formulations (F1–F5) were developed with varying concentrations of polymers and excipients. Prefor mulation studies of metronidazole including physical appearance, solubility, melting point, and UV calibration curve were carried out. The prepared patches were further evaluated for parameters such as weight uniformity, thickness, folding endurance, surface pH, moisture content, etc., The evaluation results indicated that all formulations showed satisfactory physicochemical properties and acceptable performance. Among all formulations, batch F3 exhibited better weight uniformity, optimum thickness, maximum folding endurance, and suitable surface pH, indicating good flexibility and compatibility with buccal mucosa. The study concluded that metronidazole buccal patches are a promising and effective drug delivery system for localized treatment of periodontitis with improved patient compliance.

Keywords: Metronidazole, Buccal Patch, Periodontitis, HPMC, Solvent Casting Method. INTRODUCTION In recent years, considerable research has been focused on the development of advanced drug delivery systems that can target specific sites in the body, with the aim of